Calcifediol (25-Hydroxyvitamin D3)

Calcifediol (25-Hydroxyvitamin D3) (CAS 19356-17-3) is the principal hepatic metabolite of cholecalciferol and the primary circulating storage form of vitamin D in human physiology. With a molecular weight of approximately 400.65 Da and established purity grades exceeding 98%, it occupies a distinct position in the vitamin D supply chain — sitting one biosynthetic step closer to the active hormone calcitriol than standard cholecalciferol, which is relevant to formulators requiring a more direct precursor. In pharmaceutical and nutraceutical development, calcifediol is used as an active reference standard, analytical standard, and active pharmaceutical ingredient in prescription and investigational applications. Manufacturers working on vitamin D metabolism research, clinical formulation development, or VDR-ligand-based product work will find this compound a technically precise starting material. Note that this form is not listed in Annex II of Directive 2002/46/EC and should not be positioned as a general EU food supplement ingredient without appropriate regulatory review.

For suppliers and manufacturers referencing the broader vitamin D category under EU Regulation 432/2012, authorised health claims for vitamin D include contributions to normal calcium and phosphorus absorption, maintenance of normal blood calcium levels, normal bones and teeth, normal muscle function, normal immune system function, and normal cell division. These claims apply at the category level and should be assessed individually for any finished product context. In personal care and cosmetic formulations, calcifediol is evaluated for its role as a stabiliser and functional active, particularly in applications targeting skin biology where vitamin D metabolites demonstrate relevance. Formulators in this sector typically work with small-lot quantities sourced to cosmetic-grade specifications.

The compound is available in crystalline and powder forms, with oil-based and cold-water-dispersible (CWS) preparations also accessible depending on application and end-matrix requirements. Grades include pharmaceutical (aligned with USP and Ph. Eur. reference standards), food-grade, and cosmetic-grade material, allowing procurement teams to match specification to the intended regulatory pathway. Given the high potency and cost profile of this material, it is primarily handled in small-lot formats. Standard packaging runs from 1 kg to 5 kg units for development and early-production volumes, with 25 kg drums or cartons available for established commercial programmes. Cold-chain handling and inert-atmosphere packaging are standard practice to preserve stability.

SoleChem supplies calcifediol to qualified industrial buyers across pharmaceutical, nutraceutical, food technology, and cosmetic manufacturing sectors within Europe. Documentation support, including CoA, SDS, and regulatory dossier assistance, is available on request. Bulk and custom-quantity enquiries are handled directly through our technical sales team.