Calcifediol (25-Hydroxyvitamin D3)

Calcifediol (25-Hydroxyvitamin D3) (CAS 19356-17-3) is the principal hepatic metabolite of cholecalciferol and the primary circulating storage form of vitamin D in human physiology.

Where is Calcifediol (25-Hydroxyvitamin D3) used?

• Pharmaceutical and nutraceutical development: active reference standard, analytical standard, and active pharmaceutical ingredient in prescription and investigational applications
• Vitamin D metabolism research, clinical formulation development, and VDR-ligand-based product work: technically precise starting material
• Personal care and cosmetics: stabiliser and functional active targeting skin biology
• It sits one biosynthetic step closer to the active hormone calcitriol than standard cholecalciferol.

Good to know: Not listed in Annex II of Directive 2002/46/EC; do not position as a general EU food supplement ingredient without regulatory review. EU Regulation 432/2012 health claims apply at the category level and should be assessed individually for any finished product context.

Commercial specifications

• Molecular weight approximately 400.65 Da
• Purity grades exceeding 98%
• Crystalline and powder forms; oil-based and cold-water-dispersible (CWS) preparations
• Packaging: 1 kg to 5 kg units; 25 kg drums or cartons