Ornithine aspartate

Ornithine aspartate (CAS 3230-94-2), also known as LOLA and marketed under names such as Hepamerz, is a salt formed from two amino acids used primarily in pharmaceutical manufacturing and clinical nutrition.

Where is Ornithine aspartate used?

• Pharmaceutical manufacturing: active substance in infusion solutions and oral granules for hepatic encephalopathy and liver dysfunction, where reducing elevated blood ammonia levels is the primary goal
• Metabolic agent supporting ammonia detoxification pathways for hepatology-focused drug development
• Contract formulators and API suppliers source it for finished dosage form development, including sachets, injectables, and oral liquid preparations
• Clinical nutrition: incorporated into specialized medical foods targeting patients with compromised liver function
• Cosmetic formulators have also evaluated it as a humectant and pH-buffering agent.

Good to know: Pharmaceutical applications represent the dominant commercial demand; cosmetic use is secondary.

Commercial specifications

• Purity levels typically at 98% or above to meet API requirements and USP or EP quality
• Bulk quantities for industrial manufacturing; smaller research-grade quantities for formulation development