Ethyl 3,4-dihydroxybenzoate

Ethyl 3,4-dihydroxybenzoate (CAS 3943-89-3), also known as EDHB or protocatechuic acid ethyl ester, is a synthetic ester of protocatechuic acid used across pharmaceutical, food, and cosmetic applications. It functions as an antioxidant, antimicrobial preservative, and UV stabilizer, protecting formulations and finished products from oxidative and photochemical degradation. In pharmaceutical manufacturing, it is used to stabilize active ingredients.

This compound helps extend shelf life in oral and topical dosage forms by preventing oxidation. Food and beverage producers incorporate it as an antioxidant and flavoring agent where its phenolic character contributes to stability. It is particularly effective in fat-containing systems for maintaining sensory profiles. Cosmetic and personal care formulators apply it in suncare and anti-aging products for its UV-absorbing and antioxidant properties.

These characteristics help protect both the formulation and the skin substrate from environmental damage. It also functions as a broad-spectrum antimicrobial agent in preservation systems against bacteria and fungi. The material offers activity in both leave-on and rinse-off formulations. Ethyl 3,4-dihydroxybenzoate is supplied as a white to off-white crystalline powder available in various purity specifications.

It is available in pharmaceutical-grade and technical-grade specifications to meet the requirements of different end markets. Packaging options typically range from laboratory quantities to bulk industrial supply.