Ethyl 3,4-dihydroxybenzoate

CAS Number
3943-89-3
EC Number
223-529-0
Abbreviation
EDHB

What is Ethyl 3,4-dihydroxybenzoate?

Ethyl 3,4-dihydroxybenzoate (CAS 3943-89-3), also known as EDHB or protocatechuic acid ethyl ester, is a synthetic ester of protocatechuic acid.

Where is Ethyl 3,4-dihydroxybenzoate used?

  • Pharmaceuticals: stabilises active ingredients and extends shelf life in oral and topical dosage forms by preventing oxidation
  • Food and beverage: antioxidant and flavouring agent, effective in fat-containing systems
  • Cosmetics and personal care: UV-absorbing and antioxidant properties in suncare and anti-aging products
  • Preservation systems: broad-spectrum antimicrobial activity against bacteria and fungi in leave-on and rinse-off formulations
  • It protects formulations and finished products from oxidative and photochemical degradation.

Commercial specifications

  • Various purity specifications
  • Packaging from laboratory quantities to bulk industrial supply

Other Names (Synonyms)

protocatechuic acid ethyl ester|EDHB|3,4-dihydroxybenzoic acid ethyl ester|Ethyl protocatechuate|4YGJ96WTBG|Benzoic acid, 3,4-dihydroxy-, ethyl ester

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What are the physical properties of Ethyl 3,4-dihydroxybenzoate?

Melting Point 132-134 °C
Boiling Point 275.56°C (rough estimate)
Density 1.2481 (rough estimate)
Appearance pale yellow to beige crystalline powder
Color Pale yellow to beige
Odor Phenolic
Form Crystalline Powder
Water Solubility Insoluble in water. Soluble in ethanol.
Vapor Pressure 0-9.4Pa at 20-120℃
Refractive Index 1.4500 (estimate)
Log P 1.4 at 35℃ and pH6.6

How is Ethyl 3,4-dihydroxybenzoate classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Which trade and regulatory codes apply to Ethyl 3,4-dihydroxybenzoate?

HS Code 29053990
WGK (Germany) 3
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