Ethyl bromoacetate

CAS Number
105-36-2
EC Number
203-290-9

What is Ethyl bromoacetate?

Ethyl bromoacetate (CAS 105-36-2), also known commercially as Antol, is a reactive alkylating ester used as a key building block in organic synthesis.

Where is Ethyl bromoacetate used?

  • Pharmaceutical manufacturing: intermediate in the manufacture of active pharmaceutical ingredients
  • Pharmaceutical manufacturing: precursor in the synthesis of amino acids and peptides
  • Specialty chemicals: reactive bromomethyl group enables carbon-carbon and carbon-heteroatom bond formation
  • Cosmetic and personal care: synthetic intermediate in fragrance molecule production for specific olfactory profiles
  • Flavor and fragrance chemistry: Antol is referenced as a starting material for aroma compounds requiring bromoacetate chemistry
  • Industrial applications: biocidal and preservative agent, where its reactivity toward biological nucleophiles provides antimicrobial effect
  • The chemical contributes to the construction of esters and lactones.

Commercial specifications

  • Purity specifications typically ranging from 97% to 99%+
  • Packaging options generally include drums and intermediate bulk containers suited to industrial procurement volumes

Other Names (Synonyms)

ETHYL 2-BROMOACETATE|Antol|Bromoacetic acid ethyl ester|Ethyl bromacetate|Ethyl monobromoacetate|Acetic acid, bromo-, ethyl ester|Ethoxycarbonylmethyl bromide|Acetic acid, 2-bromo-, ethyl ester

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What are the physical properties of Ethyl bromoacetate?

Melting Point -38 °C
Boiling Point 168.5 °C
Density 1.5032 g/cm³ @ Temp: 20 °C
Flash Point 118 °F
Appearance Ethyl bromoacetate is a clear, colorless to light-yellow liquid.
Color Clear
Odor Pungent odour
Form Liquid
Water Solubility Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.
Vapor Pressure 2.6 mm Hg ( 25 °C)
Refractive Index n 20/D 1.451(lit.)

How is Ethyl bromoacetate classified and handled safely? Learn More

Danger
GHS06· Toxic GHS02· Flammable GHS05· Corrosive

Hazard Statements

H226 Flammable liquid and vapor
H300 Fatal if swallowed
H310 Fatal in contact with skin
H318 Causes serious eye damage
H330 Fatal if inhaled
H300+H310+H330 Fatal if swallowed, in contact with skin or if inhaled

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Which trade and regulatory codes apply to Ethyl bromoacetate?

HS Code 29159080
UN Number 1603
ADR Class 6.1
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 1
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