Vitamin B5 Dexpanthenol (D-Panthenol)

Dexpanthenol (CAS 81-13-0), also known as pantothenyl alcohol and D-pantothenol, is the biologically active alcohol analogue of pantothenic acid (vitamin B5).

Where is Vitamin B5 Dexpanthenol (D-Panthenol) used?

• Pharmaceutical and personal care manufacturing: humectant and skin-conditioning agent
• Topical pharmaceuticals: active ingredient in wound-healing creams, nasal sprays and eye drops supporting epithelial repair and tissue regeneration
• Cosmetics: shampoos, conditioners and leave-in treatments for hair fiber moisture retention and reduced breakage
• Skin care: lotions, serums and barrier creams for sustained hydration
• Baby care and post-procedure skincare for sensitive skin
• Upon absorption into skin or hair, this pro-vitamin converts to pantothenic acid.
• Can be incorporated into both cold-processed and heated emulsions.
• A standard component in medical dermatology for diaper rash cream and post-burn care.
• In skin care, acts as a moisture-binding agent in lotions and creams, and as an active ingredient in eye hygiene and contact lens solutions.
• Used in combination products with other vitamins.

Good to know: Pharmaceutical-grade material meets USP, BP and Ph. Eur. specifications; cosmetic-grade material is also offered.

Formulation notes

• D-panthenol is the pure D-isomer, while DL-panthenol is a mixture of D- and L-isomers.
• Hydrolysed by alkali and strong acid.

Typical specification

• Viscosity of approximately 10,000 to 15,000 cP at 25°C.
• Commercially available in concentrations of 75% or 98%.

Regulatory status

• Registered and compliant under EU REACH (EC 1907/2006).
• ATC codes: A11HA30, D03AX03, and S01XA12.
• Listed in US FDA 21 CFR 310.545 and 582.5580.

Storage, packaging and handling

• Store at 15–30°C in a cool, dry, well-ventilated area.

Frequently asked questions about Vitamin B5 Dexpanthenol (D-Panthenol)

What is the optical rotation of dexpanthenol?

Dexpanthenol has an optical rotation of +29° to +31.5° at 20°C.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.