REACH
Alpha-Arbutin
CAS Number
84380-01-8
EC Number
617-565-9
What is Alpha-Arbutin?
Alpha-Arbutin (CAS 84380-01-8) is a biosynthetic skin-brightening active used in personal care formulations.
Where is Alpha-Arbutin used?
- Hyperpigmentation treatments: primary active in dark spot serums and brightening creams
- Tonal and complexion products: brightening function and secondary humectant benefit in BB creams and foundation primers
- Combination actives with niacinamide, vitamin C derivatives, or kojic acid
- Pharmaceutical-grade batches serve as intermediates in skin-active compound synthesis and topical drug formulations.
Good to know: A stable, high-efficacy alternative to hydroquinone or beta-arbutin. It inhibits melanin synthesis by blocking tyrosinase activity.
Commercial specifications
- Cosmetic grade: purity typically 99% or higher, verified by HPLC
- Pharmaceutical-intermediate grades with full documentation packages
- Documentation: COA, residual solvent testing, stability data
Other Names (Synonyms)
α-arbutin|(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
What are the physical properties of Alpha-Arbutin?
Melting Point 200-201 °C
Boiling Point 561.6±50.0 °C(Predicted)
Density 1.556±0.06 g/cm3(Predicted)
Color White to Off-White
Form Solid
How is Alpha-Arbutin classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H302 Harmful if swallowed
Precautionary Statements
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.
P501 Dispose of contents/container in accordance with local regulations.
P301+P317 Get emergency medical help.
Which trade and regulatory codes apply to Alpha-Arbutin?
HS Code 2938.90.0000
Storage Class 11 - Combustible Solids
WGK (Germany) 3