SoleChem

4-butylresorcinol

Organic Acids Pharmaceuticals & Healthcare
CAS
18979-61-8
EC
606-191-2
Mol. Weight
166.22 g/mol

Description

4-Butylresorcinol (CAS 18979-61-8), commercially recognized as Rucinol, is a synthetic depigmentation active used in cosmetic and pharmaceutical formulations. It inhibits tyrosinase and peroxidase enzymes involved in melanin synthesis.

This makes it a targeted ingredient for skin-brightening and hyperpigmentation correction products. In premium skincare, it is formulated into serums, creams, and spot treatments targeting melasma and age spots.

It is often used at concentrations between 0.1% and 1% for post-inflammatory hyperpigmentation. Pharmaceutical topical preparations use it as an active ingredient in prescription and OTC depigmenting products.

Regulatory-grade purity is required for these applications to ensure safety and efficacy. Its antioxidant activity also supports use as a stabilizer in formulations where oxidative degradation is a concern.

Some specialty formulations incorporate it for its mild preservative-boosting effect alongside primary systems. 4-Butylresorcinol is supplied as a white to off-white crystalline powder for industrial use.

It is available in cosmetic-grade and pharmaceutical-grade specifications. High-purity grades, typically ≥98% or ≥99% by HPLC, are standard for active cosmetic ingredient supply chains.

Packaging ranges from small quantities for R&D sampling to kilogram-scale lots for commercial batches. This ensures flexibility for both laboratory development and large-scale manufacturing needs.

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Physical Properties

Melting Point 49-50 °C
Boiling Point 155-175 °C @ Press: 7 Torr
Density 1.092±0.06 g/cm3(Predicted)
Color white to pale yellow powder
Odor Characteristic
Form Powder
Vapor Pressure 0.041Pa at 25℃
Log P 2.8 at 24℃ and pH7

Safety & Handling (Learn More)

Warning GHS07 GHS09
Hazard Statements
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H400 Very toxic to aquatic life
Precautionary Statements
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P391 Collect spillage.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P301+P317 Get emergency medical help.
P302+P352 IF ON SKIN: Wash with plenty of water.
P332+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 2907290090
Storage Class 13 - Non Combustible Solids
WGK (Germany) 2

Documentation

Other Names

Rucinol (TN)|4-butylbenzene-1,3-diol|Rucinol|1,3-Benzenediol, 4-butyl-|4-n-Butylresorcinol|Resorcinol, 4-butyl-|4-Butylresorcin

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