Organic Acids
REACH
Glycyrrhetinic acid
CAS Number
471-53-4
EC Number
207-444-6
Industries: Personal Care & Cosmetics
What is Glycyrrhetinic acid?
Glycyrrhetinic acid (CAS 471-53-4), also known as uralenic acid, is a pentacyclic triterpenoid derived from licorice root extract.
Where is Glycyrrhetinic acid used?
- Personal care and cosmetics: skin-conditioning active
- Cosmetic formulations: anti-inflammatory creams, serums, spot-treatment products
- Whitening and brightening preparations: tyrosinase modulator that reduces the appearance of hyperpigmentation and redness
- Flavor industry: flavoring agent and acidulant in confectionery and oral care products
- Tobacco flavoring systems: licorice character
- It appears in topical pharmaceutical preparations addressing minor skin irritation.
Commercial specifications
- Purity typically 95% to 98% by HPLC
- Bulk quantities in kilogram and multi-kilogram packaging
Other Names (Synonyms)
Uralenic acid|Glycyrrhetic Acid|beta-Glycyrrhetic acid|b-Glycyrrhetic acid|alpha-Glycyrrhetinic acid|a-Glycyrrhetinic acid|3b-Hydroxy-11-oxoolean-12-en-30-oic acid|3b-Hydroxy-11-oxoolean-12-en-30-oate
What are the physical properties of Glycyrrhetinic acid?
Melting Point 296 °C
Boiling Point 687.4 °C
Density 0.9967 (rough estimate)
Appearance white or greyish-white crystalline powder
Color White to off-white
Form Crystalline Powder
Water Solubility SOLUBLE IN ACETIC ACID
Vapor Pressure 10-220Pa at 20-50℃
Refractive Index 162 ° (C=1, MeOH)
Log P 4.5 at 20℃
How is Glycyrrhetinic acid classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H302 Harmful if swallowed
H319 Causes serious eye irritation
Precautionary Statements
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P330 Rinse mouth.
Which trade and regulatory codes apply to Glycyrrhetinic acid?
HS Code 29189900
Storage Class 11 - Combustible Solids
WGK (Germany) 3