Sodium hyaluronate

Sodium hyaluronate (CAS 9067-32-7), the sodium salt form of hyaluronic acid (HA), is a high-molecular-weight polysaccharide sourced from microbial fermentation or animal-derived raw materials.

Where is Sodium hyaluronate used?

• Cosmetic, pharmaceutical and biomedical formulations: humectant, film-former and viscosity modifier
• Skincare and topical products: binds moisture to the skin surface and improves texture in serums, creams and sheet masks; used as a main active in face serums for deep hydration and plumping effects at a typical use level of 0.1% to 1%.
• Ophthalmic: viscoelastic agent in cataract procedures and base for eye drop formulations targeting dry eye syndrome
• Intra-articular injectable grades act as a synovial fluid supplement in viscosupplementation therapies for osteoarthritis.
• Biotechnology: scaffold material
• Cross-linked powder is used as a pre-formed three-dimensional polymer network for dermal filler and medical injection applications.
• Hair care products: improves scalp hydration and hair fiber moisture retention.

Good to know: Molecular weight selection determines depth of hydration. Molecular weight and purity specifications are the primary procurement differentiators across end-use segments.

Formulation notes

• Soluble in pure water, sodium hydroxide solution, or PBS.
• Offers better stability and skin penetration compared to ordinary hyaluronic acid.
• The sodium salt of hyaluronic acid; more water-soluble and stable in formulation than the free acid.

Typical specification

• Heavy metals limit of maximum 20 ppm.
• The 3% solution has an endotoxin limit of not more than 0.5 EU/mL.
• pH in pure water is between 5.0 and 8.5.
• High-molecular-weight grades typically have a molecular weight of 2.8–3.2 million daltons.
• A 1.4% solution typically has a viscosity of about 400,000 mPa·s.

Regulatory status

• INCI name is Sodium Hyaluronate.
• Classified under CN code 3913.90 (natural polymers and modified natural polymers, not elsewhere specified).

Storage, packaging and handling

• Store at 2-8 °C.

Frequently asked questions about Sodium hyaluronate

What molecular weight grades are available?

Low, medium, and high molecular weight grades are available.

What are the purity and protein content specifications?

Purity is at least 95%, and protein content is maximum 0.1%.

What are the applications in biomedical and tissue engineering?

It is used in tissue engineering and drug delivery systems as a biomaterial due to its immuno-neutrality.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.