Amines
REACH
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
CAS Number
1892-57-5
EC Number
217-579-2
Abbreviation
EDC
Industries: Pharma & Healthcare
What is 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide?
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (CAS 1892-57-5), commonly known as EDC or EDCI, is a water-soluble carbodiimide coupling reagent used to form stable amide and ester bonds.
Where is 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide used?
- Industry: zero-length crosslinker that activates carboxylic acids for conjugation without becoming part of the final bond
- Bioconjugation: antibody-antigen coupling, protein-to-surface immobilization, diagnostic assay development
- Pharmaceutical manufacturing: peptide synthesis and drug-protein conjugates
- Personal care: crosslinking hyaluronic acid and other polysaccharides in dermal filler and hydrogel systems
- Biosensors, lateral flow devices and conjugate vaccines rely on EDC as a primary activation agent.
Commercial specifications
- Hydrochloride salt form is the dominant commercial grade due to superior stability under ambient storage conditions
- Research quantities through to multi-kilogram lots
Other Names (Synonyms)
EDAC|EDCI|ETHYLDIMETHYLAMINOPROPYL CARBODIIMIDE|RJ5OZG6I4A|1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-|3-(3-dimethylaminopropyl)-1-ethylcarbodiimide|1,3-Propanediamine, N3-(ethylcarbonimidoyl)-N1,N1-dimethyl-|Carbodiimide, [3-(dimethylamino)propyl]ethyl-|EDC
What are the physical properties of 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide?
Boiling Point 45 °C @ Press: 1 Torr
Density 0.877 g/mL at 20 °C(lit.)
Flash Point 66-68°C/1mm
Color Colorless to slightly yellow
Form Liquid
Water Solubility Soluble in water.
Refractive Index n 20/D 1.461
How is 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard
Hazard Statements
H302 Harmful if swallowed
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H315 Causes skin irritation
Precautionary Statements
P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
Which trade and regulatory codes apply to 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide?
HS Code 29252900
UN Number 2735
ADR Class 8
Packing Group III
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
WGK (Germany) 3