Dicyclohexylcarbodiimide
CAS Number
538-75-0
EC Number
208-704-1
Abbreviation
DCC
What is Dicyclohexylcarbodiimide?
Dicyclohexylcarbodiimide (CAS 538-75-0), commonly known as DCC, is a coupling reagent used in pharmaceutical synthesis, peptide chemistry, and specialty chemical manufacturing.
Where is Dicyclohexylcarbodiimide used?
- Pharmaceutical API synthesis: drives amide bond formation in active ingredient production
- Peptide manufacturing: standard coupling agent in solution-phase and solid-phase workflows
- Flavor and fragrance chemistry: facilitates ester synthesis for aroma compounds
- Cosmetic formulators use it in the synthesis of specialty esters and functional ingredients.
Commercial specifications
- Technical and high-purity reagent grades
- Suitable for GMP synthesis environments
- Packaging from laboratory-scale quantities to bulk supply
Other Names (Synonyms)
N,N'-methanetetraylbiscyclohexaamine|N,N'-methanediylidenedicyclohexanamine|N,N'-dicyclohexylcarbodiimide|DCCD|bis(cyclohexyl)carbodiimide|DCCI|DCC|1,3-dicyclohexylcarbodiimide
What are the physical properties of Dicyclohexylcarbodiimide?
Melting Point 34.5 °C
Boiling Point 112 °C @ Press: 3.5 Torr
Density 1.247 g/mL at 25 °C
Flash Point 190 °F
Appearance N,N0 -Dicyclohexylcarbodiimide (DCC) is a white crystalline solid. Odor is sweet and heavy.
Color White to pale yellow
Form Waxy Solid or Crystalline Mass
Water Solubility Reaction
Vapor Pressure 1.044-1.15Pa at 20-25℃
Refractive Index n 20/D 1.48
Log P 5.567-6.83 at 25℃
How is Dicyclohexylcarbodiimide classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS09· Environmental Hazard GHS08· Health Hazard
Hazard Statements
H302 Harmful if swallowed
H311 Toxic in contact with skin
H315 Causes skin irritation
H317 May cause an allergic skin reaction
Precautionary Statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Dicyclohexylcarbodiimide?
HS Code 29251900
UN Number 2922
ADR Class 8
Packing Group II
Storage Class 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects
WGK (Germany) 3