SoleChem

4-Hydroxy-TEMPO

Heterocyclic Compounds Personal Care & Cosmetics
CAS
2226-96-2
EC
218-760-9
Mol. Weight
172.24 g/mol
Abbreviation
TEMPOL

Description

4-Hydroxy-TEMPO (CAS 2226-96-2), commercially known as TEMPOL, is a stable nitroxide radical used across polymer, pharmaceutical, and personal care manufacturing. It functions primarily as a polymerization inhibitor and radical scavenger.

This chemical acts as a process stabilizer, preventing premature crosslinking or degradation during production and storage. In polymer and resin manufacturing, it inhibits unwanted radical polymerization in monomer streams.

By protecting product integrity during transport and storage, it ensures high-quality outcomes. Pharmaceutical manufacturers use it as a controlled radical mediator in active ingredient synthesis and as an antioxidant stabilizer.

In personal care, it is incorporated into formulations requiring oxidative stability. This is particularly important where free radical chain reactions would compromise shelf life or efficacy in the final consumer product.

TEMPOL also serves as a catalyst in selective oxidation reactions, including the conversion of primary alcohols to aldehydes. This functionality is essential in fine chemical and API synthesis workflows for modern medicine.

The product is supplied as a crystalline solid, typically as an orange to red-orange powder or granules. It is available in technical and high-purity grades, with purity specifications commonly ranging from 97% to 99%+.

These grades are suitable for research, pharmaceutical, and industrial applications. Packaging options range from small laboratory quantities to bulk industrial supply, depending on specific application requirements and scale.

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Physical Properties

Melting Point 71-73 °C
Boiling Point 302.58°C (rough estimate)
Density 1.0402 (rough estimate)
Flash Point 146°(295°F)
Appearance solid
Color Orange
Form Crystals or Crystalline Powder
Water Solubility soluble
Vapor Pressure 0.025Pa at 20℃
Refractive Index 1.4350 (estimate)
pH 8.2 (20g/l, H2O, 20℃)
Log P 0.56 at 25℃

Safety & Handling (Learn More)

Danger GHS05 GHS07 GHS08
Hazard Statements
H302 H302
H315 H315
H318 H318
H319 H319
H335 H335
H373 H373
H412 H412
Precautionary Statements
P260 P260
P261 P261
P264 P264
P270 P270
P271 P271
P273 P273
P280 P280
P317 P317
P319 P319
P321 P321
P330 P330
P405 P405
P501 P501
P264+P265 P264+P265
P301+P317 P301+P317
P302+P352 P302+P352
P304+P340 P304+P340
P332+P317 P332+P317
P337+P317 P337+P317
P362+P364 P362+P364
P403+P233 P403+P233
P305+P351+P338 P305+P351+P338
P305+P354+P338 P305+P354+P338

Trade & Regulatory

HS Code 29333999
Storage Class 11 - Combustible Solids
WGK (Germany) 1

Documentation

Other Names

Tempol

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