2,4,5-Trimethyl-3-oxazoline
Description
2,4,5-Trimethyl-3-oxazoline (CAS 22694-96-8), also recognized in the flavor industry under FEMA No. 3525, is a heterocyclic oxazoline compound used as a specialty aroma chemical and pharmaceutical building block.
Its roasted, nutty odor profile positions it as a functional ingredient in flavor formulation, while its reactive oxazoline ring makes it a useful intermediate in synthetic chemistry applications.
In flavor and fragrance manufacturing, it contributes characteristic roasted and cocoa-like notes to food products, beverages, and tobacco formulations where controlled dosing is critical to end-product quality.
Pharmaceutical and biotech researchers employ the oxazoline scaffold as a synthetic intermediate for constructing more complex heterocyclic APIs and research compounds for various clinical studies.
It also serves synthetic chemists in the preparation of chiral auxiliaries and ligands used in asymmetric catalysis workflows. Contract manufacturers sourcing building blocks evaluate it for its ring-opening reactivity.
2,4,5-Trimethyl-3-oxazoline is supplied as a liquid, typically at high purity levels suited to both flavor and pharmaceutical research applications. Standard offerings include technical-grade and research-grade material.
Documentation is aligned to FEMA-recognized flavor ingredient requirements where applicable. Packaging ranges from small quantities for laboratory use to larger volumes for industrial flavor production.
Physical Properties
| Boiling Point | 45-47°C 12mm |
| Density | 0,919 g/cm 3 |
| Flash Point | 45-47°C/12mm |
| Appearance | Yellow-orange liquid; powerful, musty, nut-like odor. Soluble in alc, propylene glycol,water; insoluble in fixed oils. |
| Odor | at 0.10 % in dipropylene glycol. musty nutty vegetable cocoa nut skin bread crust phenolic woody |
| Form | liquid |
| Water Solubility | Soluble in alcohol, fixed oils. Insoluble in water. |
| Log P | 1.72 |
Safety & Handling (Learn More)
Trade & Regulatory
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 3 |
Documentation
Other Names
2,5-Dihydro-2,4,5-trimethyloxazole|3-Oxazoline, 2,4,5-trimethyl-|Oxazole, 2,5-dihydro-2,4,5-trimethyl-|peanut oxazole|2,4,5-trimethyl-delta-3-oxazoline|PEANUT FLAVOR
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