SoleChem

n-octyl pyrrolidone

Solvents Pharmaceuticals & Healthcare
CAS
2687-94-7
EC
403-700-8
Mol. Weight
197.32 g/mol

Description

N-Octyl Pyrrolidone (CAS 2687-94-7), commonly abbreviated as NOP, is a high-boiling, low-volatility pyrrolidone solvent used across pharmaceutical, coatings, and personal care manufacturing.

It functions as a solvent, wetting agent, and dispersant where conventional solvents present regulatory or performance limitations. In coatings and adhesives, NOP improves pigment dispersion and substrate wetting.

This enables more uniform film formation on difficult surfaces including plastics and metals. Personal care formulators use it as a solvent and penetration enhancer in topical products such as hair treatments.

In skin conditioners, it aids active ingredient delivery. In pharmaceutical manufacturing, it supports drug solubilization and membrane permeation in transdermal and topical dosage forms.

Industrial cleaning and agrochemical formulations rely on NOP's emulsification and surface-modification properties. These characteristics improve active distribution and contact efficiency across various applications.

N-Octyl Pyrrolidone is supplied as a clear liquid in standard drum and IBC quantities. Technical-grade material is the primary commercial form for most industrial and chemical processing needs.

High-purity grades are available for pharmaceutical and personal care applications. Buyers should confirm purity specifications and regulatory compliance documentation when sourcing for regulated end markets.

Documentation such as REACH registration status is essential for compliance. This ensures the material meets the necessary safety and quality requirements for global distribution and manufacturing.

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Physical Properties

Melting Point -25 °C
Boiling Point 170-172 °C
Density 0.91845 g/cm³ @ Temp: 25 °C
Flash Point >230 °F
Color Colorless to Yellow
Form clear liquid
Water Solubility 1.14-1.25g/L at 20℃
Vapor Pressure 0.03-0.08Pa at 20℃
Refractive Index n 20/D 1.465(lit.)
Log P 4.15 at 20℃

Safety & Handling (Learn More)

Danger GHS05 GHS09
Hazard Statements
H314 Causes severe skin burns and eye damage
H318 Causes serious eye damage
H411 Toxic to aquatic life with long lasting effects
Precautionary Statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P316 Get emergency medical help immediately.
P317 Get emergency medical help.
P321 Specific treatment (see … on this label).
P363 Wash contaminated clothing before reuse.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P301+P330+P331 Rinse mouth. Do NOT induce vomiting.
P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29339900
UN Number 3267
ADR Class 8
Packing Group II
WGK (Germany) 2

Documentation

Other Names

N-Octyl-2-pyrrolidone|1-Octyl-2-pyrrolidinone|1-Octyl-2-pyrrolidone|2-Pyrrolidinone, 1-octyl-|n-(n-octyl)-2-pyrrolidone|RefChem:828515|Surfadone LP 100|NOP

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