Terephthalaldehyde

CAS Number
623-27-8
EC Number
210-784-8
Abbreviation
TPA

What is Terephthalaldehyde?

Terephthalaldehyde (CAS 623-27-8), also known as 1,4-Benzenedicarboxaldehyde, is a bifunctional aromatic dialdehyde used as a reactive building block and crosslinking agent in polymer chemistry and pharmaceutical synthesis.

Where is Terephthalaldehyde used?

  • Polymer and materials science: monomer for synthesizing polyimines
  • Covalent organic frameworks and high-performance resins requiring precise crosslink density
  • Pharmaceutical and biotech: intermediate in active ingredient synthesis
  • Protein crosslinker for diagnostic reagents and bioconjugation workflows
  • Personal care: fragrance formulations
  • Antimicrobial and preservation applications in industrial disinfection and surface treatment
  • Its two aldehyde groups enable controlled condensation and crosslinking reactions.

Commercial specifications

  • Technical and high-purity grades, with reagent- and synthesis-grade specifications
  • Packaging from kilogram quantities for laboratory and development use to bulk quantities for industrial-scale production

Other Names (Synonyms)

1,4-Benzenedicarboxaldehyde|1,4-Phthalaldehyde|M2Y6E4N2TS|P-DIFORMYLBENZENE|Terephthalic aldehyde|1,4-Diformylbenzene|p-Benzenedicarboxaldehyde|TPA

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What are the physical properties of Terephthalaldehyde?

Melting Point 117 °C
Boiling Point 290 °C
Density 1.519 g/cm³
Flash Point 76 °C
Appearance WHITE TO LIGHT YELLOW CRYSTALLINE POWDER
Color White to light yellow
Form Crystalline Powder
Water Solubility 3 g/L (50 ºC)
Vapor Pressure 0.25-0.46Pa at 20-25℃
Refractive Index 1.4800 (estimate)
Log P 1 at 20.1℃ and pH6.6-6.8

How is Terephthalaldehyde classified and handled safely? Learn More

Danger
GHS06· Toxic GHS07· Irritant

Hazard Statements

H302 Harmful if swallowed
H311 Toxic in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H331 Toxic if inhaled
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.

Which trade and regulatory codes apply to Terephthalaldehyde?

HS Code 29122900
WGK (Germany) 1
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