Phthalaldehyde

CAS Number
643-79-8
EC Number
211-402-2
Abbreviation
OPA

What is Phthalaldehyde?

o-Phthalaldehyde (CAS 643-79-8), commonly abbreviated as OPA, is an aromatic dialdehyde used in pharmaceutical, personal care, and specialty chemical manufacturing.

Where is Phthalaldehyde used?

  • Healthcare: active biocidal agent in cold sterilization solutions for heat-sensitive medical instruments, particularly endoscopes
  • Pharmaceutical manufacturing: synthetic building block in the production of APIs and heterocyclic compounds
  • Analytical chemistry and diagnostics: fluorometric reagent for detecting primary amines and amino acids in HPLC workflows
  • Personal care: antimicrobial properties in preservation systems for rinse-off and professional-use products
  • It functions primarily as a high-level disinfectant and chemical intermediate.

Good to know: It often outperforms glutaraldehyde in speed and efficacy for clinical applications. Buyers should confirm purity specifications against USP or equivalent compendial standards depending on requirements.

Commercial specifications

  • High-purity synthesis-grade material suitable for pharmaceutical intermediates

Other Names (Synonyms)

1,2-benzenedicarboxaldehyde|o-phthalaldehyde|OPA

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What are the physical properties of Phthalaldehyde?

Melting Point 56 °C
Boiling Point 83-84 °C (0.7501 mmHg)
Density 1.13
Flash Point >230 °F
Appearance Light yellow powder
Color yellow
Form powder
Water Solubility soluble
Vapor Pressure 0.56Pa at 25℃
Refractive Index 1.4500 (estimate)
pH 7 (53g/l, H2O, 20℃)
Log P 0.99 at 30℃

How is Phthalaldehyde classified and handled safely? Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard

Hazard Statements

H228 Flammable solid
H301 Toxic if swallowed
H314 Causes severe skin burns and eye damage
H315 Causes skin irritation

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Which trade and regulatory codes apply to Phthalaldehyde?

HS Code 29122900
UN Number 2923
ADR Class 8
Packing Group II
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
WGK (Germany) 3
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