SoleChem

Norfloxacin

CAS
70458-96-7
EC
274-614-4
Mol. Weight
319.33 g/mol

Description

Norfloxacin (CAS 70458-96-7) is a second-generation fluoroquinolone antibiotic active ingredient used in pharmaceutical manufacturing. It functions as a broad-spectrum antibacterial agent targeting both gram-positive and gram-negative organisms.

This makes it a core API in finished dosage form production for global markets. In pharmaceutical formulation, it is the active ingredient in oral tablets and suspensions indicated for urinary tract and gastrointestinal bacterial infections.

Ophthalmic and otic preparations incorporate it as the primary antibacterial component in drops and solutions for ocular and ear infections. Contract manufacturers and generic drug producers source it as a pharmaceutical intermediate.

It is frequently used for the synthesis of related fluoroquinolone derivatives in laboratory settings. Topical antimicrobial formulations in the personal care and pharmaceutical space also utilize it for preservation and infection control.

These applications are specific to regulated product categories requiring high-purity ingredients. The product is supplied as a white to pale yellow crystalline powder for industrial use. It is available in pharmaceutical-grade specifications.

These include USP, BP, and Ph. Eur. standards, with purity levels typically at 99% or above to meet API requirements. Bulk quantities are standard for industrial and contract manufacturing procurement.

Smaller research-grade quantities are also available through specialty chemical distributors for testing. This ensures that manufacturers can maintain consistent quality across various production scales and regulatory environments.

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Physical Properties

Melting Point 227-228 °C
Boiling Point 555.8±50.0 °C(Predicted)
Density 1.2504 (estimate)
Appearance Off-white to light yellow cryst powder
Color White to yellow
Form Crystalline Powder
Water Solubility Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water

Safety & Handling (Learn More)

Danger GHS05 GHS07 GHS08
Hazard Statements
H318 Causes serious eye damage
H319 Causes serious eye irritation
H361 Suspected of damaging fertility or the unborn child
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P317 Get emergency medical help.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29335900
WGK (Germany) 2

Documentation

Other Names

Quinabic|Noroxin|NFLX|MK-366|Chibroxin|Baccidal|1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid|1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

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