Metronidazole
CAS Number
443-48-1
EC Number
207-136-1
What is Metronidazole?
Metronidazole (CAS 443-48-1) is an antiprotozoal and antibacterial active pharmaceutical ingredient used in human and veterinary medicine.
Where is Metronidazole used?
- Prescription drugs: core API targeting anaerobic bacteria and protozoa
- Oral tablets, suspensions and intravenous solutions for infections caused by anaerobic organisms, including bacterial vaginosis, trichomoniasis and Clostridioides difficile
- Topical gels and creams for dermatological indications such as rosacea management
- Veterinary oral and injectable preparations for gastrointestinal anaerobic infections in companion animals and livestock
- In select anti-redness and skin-calming cosmetic products it appears where regulatory frameworks permit.
Commercial specifications
- USP, BP and Ph. Eur. pharmacopoeial grades
- API-grade material is the standard commercial form
- Micronized particle size variants support formulation requirements and bioavailability
Other Names (Synonyms)
2-methyl-5-nitroimidazole-1-ethanol|2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole|2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole|1-(β-oxyethyl)-2-methyl-5-nitroimidazole|1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole|1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole|1-(beta-oxyethyl)-2-methyl-5-nitroimidazole|1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole
What are the physical properties of Metronidazole?
Melting Point 158-160 °C
Boiling Point 301.12°C (rough estimate)
Density 1.45 g/cm³
Flash Point 9°C
Appearance Metronidazole is an odorless, white, yellow, or cream-colored crystalline solid. Darkens on exposure to light. Bitter, salty taste (do not test).
Color white to light yellow
Form crystalline
Water Solubility <0.1 g/100 mL at 20 ºC
Refractive Index 1.5800 (estimate)
Log P -0.02
How is Metronidazole classified and handled safely? Learn More
Danger
GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H302 Harmful if swallowed
H312 Harmful in contact with skin
H332 Harmful if inhaled
H341 Suspected of causing genetic defects
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Metronidazole?
HS Code 29332990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
WGK (Germany) 3