Borane-tetrahydrofuran

Borane-tetrahydrofuran (CAS 14044-65-6), commonly referenced as BH3·THF, is a stabilized borane complex supplied as a solution in tetrahydrofuran. It delivers reactive borane in a handleable liquid form. This chemical enables controlled hydroboration and reduction chemistry across pharmaceutical and industrial synthesis. In pharmaceutical manufacturing, it is used to reduce carboxylic acids, amides, and oximes to their corresponding alcohols and amines.

These transformations are difficult to achieve cleanly with conventional reducing agents. It initiates ring-opening polymerization of cyclic monomers, making it a useful catalyst precursor in specialty polymer production. Agrochemical synthesis relies on it for constructing chiral intermediates where stereoselective hydroboration is required. Biotechnology and life sciences research also draw on it for synthesizing boron-containing building blocks.

These blocks are used in enzyme inhibitor development and labeled compound preparation. The product is supplied as a solution in tetrahydrofuran, with 1.0 M concentration being the most commercially standard form. Higher concentration solutions are available for industrial-scale processes where solvent minimization is a priority. It is sourced primarily to pharmaceutical-grade and reagent-grade specifications for various applications.

Packaging ranges from laboratory quantities to bulk containers suited for manufacturing use. The material is handled according to strict safety protocols to maintain stability and reactivity during transport and storage.