Borane-tetrahydrofuran

Borane-tetrahydrofuran (CAS 14044-65-6), commonly referenced as BH3·THF, is a stabilized borane complex in tetrahydrofuran solution.

Where is Borane-tetrahydrofuran used?

• Pharmaceutical manufacturing: reduces carboxylic acids, amides and oximes to alcohols and amines
• Specialty polymer production: catalyst precursor that initiates ring-opening polymerization of cyclic monomers
• Agrochemical synthesis: constructs chiral intermediates via stereoselective hydroboration
• Biotechnology and life sciences research: synthesizes boron-containing building blocks for enzyme inhibitor development and labeled compound preparation
• It enables controlled hydroboration and reduction chemistry in industrial synthesis.

Good to know: These transformations are difficult to achieve cleanly with conventional reducing agents.

Commercial specifications

• 1.0 M solution in tetrahydrofuran, the most commercially standard form
• Higher concentration solutions for industrial-scale processes where solvent minimization is a priority
• Packaging from laboratory quantities to bulk containers for manufacturing use