2-methyltetrahydrofuran

2-Methyltetrahydrofuran (CAS 96-47-9), or 2-MeTHF, is a cyclic ether solvent derived from renewable feedstocks such as furfural.

Where is 2-methyltetrahydrofuran used?

• Synthesis and extraction: direct replacement for tetrahydrofuran
• Pharmaceutical manufacturing: reaction solvent for Grignard reactions and organolithium chemistry
• Catalytic hydrogenations: tolerance to aqueous workup simplifies downstream processing
• Personal care: carrier solvent for active ingredient dissolution and extraction during raw material processing
• Flavors and fragrances: minor use for specific ethereal notes
• It offers improved water immiscibility and a higher boiling point than traditional alternatives.

Good to know: Its partial bio-based origin supports green chemistry compliance in API synthesis, a decisive factor in supplier qualification. Stabilized variants prevent peroxide formation; buyers should confirm inhibitor type and water content when sourcing for sensitive synthetic applications.

Commercial specifications

• Standard packaging ranges from drums to ISO tank quantities
• Technical grade and high-purity anhydrous grades are commonly traded
• Stabilized variants available for extended storage