2-methyltetrahydrofuran

2-Methyltetrahydrofuran (CAS 96-47-9), commonly abbreviated as 2-MeTHF, is a cyclic ether solvent derived from renewable feedstocks such as furfural. It functions as a direct replacement for tetrahydrofuran in synthesis and extraction processes. This solvent offers improved water immiscibility and a higher boiling point compared to traditional alternatives. In pharmaceutical manufacturing, it is used as a reaction solvent for Grignard reactions and organolithium chemistry.

Its tolerance to aqueous workup conditions simplifies downstream processing during catalytic hydrogenations. Its partial bio-based origin supports green chemistry compliance in API synthesis, which is a decisive factor in supplier qualification. Personal care formulators use it as a carrier solvent for active ingredient dissolution and extraction steps during raw material processing. A minor application exists in flavors and fragrances for specific ethereal notes.

The product is supplied as a clear liquid in standard packaging ranging from drums to ISO tank quantities. Technical grade and high-purity anhydrous grades are the most commonly traded specifications for industrial use. Stabilized variants are available for extended storage to prevent peroxide formation. Buyers should confirm inhibitor type and water content specifications when sourcing for sensitive synthetic applications to ensure performance.