L-citrulline

CAS Number
372-75-8
EC Number
206-759-6

What is L-citrulline?

L-Citrulline (CAS 372-75-8) is a non-essential amino acid naturally occurring in watermelon and produced endogenously in the urea cycle.

Where is L-citrulline used?

  • Sports nutrition: primary active ingredient in pre-workout powders and capsules targeting exercise performance and muscle recovery
  • Pharmaceuticals: active or supporting ingredient in formulations addressing urea cycle disorders and cardiovascular-related indications
  • Functional food and beverage: incorporated into fortified drinks and nutritional bars where amino acid enrichment is a label claim
  • Personal care: included in topical products for moisture retention and skin barrier support
  • It functions as a precursor to L-arginine and supports nitric oxide pathway activity.

Good to know: Food-grade material meets FCC standards for ingestible products and dietary supplement manufacturing; pharmaceutical-grade material is subject to tighter purity and testing requirements for global regulatory compliance.

Commercial specifications

  • Bulk quantities available

Other Names (Synonyms)

δ-ureidonorvaline|α-amino-δ-ureidovaleric acid|N5-carbamoylornithine|N5-Carbamoyl-L-ornithine|N5-(Aminocarbonyl)ornithine|N(delta)-Carbamylornithine|N(5)-(Aminocarbonyl)-L-ornithine|L-2-Amino-5-ureidovaleric acid

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What are the physical properties of L-citrulline?

Melting Point 235.5 °C
Boiling Point 306.48°C (rough estimate)
Density 1.384 g/cm³ (solid)
Appearance White powder
Color White
Odor Odorless
Form Crystals or Crystalline Powder
Water Solubility 200 g/L (20 ºC)
Refractive Index 26 ° (C=8, 6mol/L HCl)
Log P -3.190

How is L-citrulline classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation

Precautionary Statements

P264 Wash … thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P264+P265 Wash … thoroughly after handling.

Which trade and regulatory codes apply to L-citrulline?

HS Code 29241900
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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