Ascaridole
Description
Ascaridole (CAS 512-85-6) is a naturally occurring bicyclic monoterpene endoperoxide isolated primarily from chenopodium oil, where it constitutes the majority of the active fraction. Historically significant as one of the first natural compounds with confirmed antiparasitic activity, it serves as a reference compound.
It is utilized as a synthetic intermediate in pharmaceutical and agrochemical research programs. In pharmaceutical development, it is used as a starting material or structural reference for synthesizing novel antiparasitic and antimicrobial candidates.
This is particularly relevant where endoperoxide pharmacophores are under investigation. Agrochemical researchers evaluate it as a biocidal active in formulations targeting soil-borne pathogens and certain pest species, drawing on its documented activity.
Its endoperoxide bridge makes it a relevant model compound in oxidative chemistry studies aimed at developing new crop protection actives. Specialty chemical suppliers also offer it to academic and industrial laboratories conducting natural product synthesis.
It is frequently used for comparative bioactivity screening in various laboratory settings. The product is supplied as a liquid, typically at high purity grades suited to research and pharmaceutical intermediate applications.
It is available in small to moderate quantities through specialty fine chemical and reference standard suppliers, reflecting its niche positioning outside bulk commodity markets. This ensures high quality for specialized industrial needs.
Certificate of Analysis documentation with purity confirmation by GC or HPLC is standard for procurement at research and pharmaceutical grades. This documentation ensures the material meets the rigorous requirements of modern chemical manufacturing and testing.
Physical Properties
| Melting Point | 3.3 °C |
| Boiling Point | 39-40 °C @ Press: 0.2 Torr |
| Density | 1.0115 g/cm³ @ Temp: 20 °C |
| Flash Point | 55.9±28.6°C |
| Color | Colorless unstable liquid |
| Form | Liquid |
| Refractive Index | 1.4769 (589.3 nm, 25℃) |
| Log P | 2.244 (est) |
Documentation
Other Names
1,4-peroxy-p-menth-2-ene|1,4-peroxido-p-menthene-2|1,4-epidioxy-p-menth-2-ene|1-methyl-4-(1-methylethyl)-2,3-dioxabicyclo[2.2.2]oct-5-ene|1-isopropyl-4-methyl-2,3-dioxabicyclo[2.2.2]oct-5-ene|Ascaridol|Ascaricum|Ascarisin
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