Disodium guanylate

Disodium guanylate (CAS 5550-12-9), also known as E627 and GMP-Na2, is a nucleotide-based flavor enhancer derived from guanosine 5'-monophosphate.

Where is Disodium guanylate used?

• Food: amplifies savory, umami taste at low use levels
• Processed food: synergistic with glutamates to boost flavor intensity
• Soups, snacks, instant noodles, sauces and seasoning mixes: combined with disodium inosinate and monosodium glutamate
• Savory snack coatings and dry seasoning blends: small concentrations deliver significant taste-boosting effects
• It allows formulators to reduce total glutamate content while maintaining perceived flavor strength.
• Personal care formulators have explored nucleotide ingredients for skin-conditioning applications.

Good to know: A key cost and label consideration for manufacturers is the reduction of total glutamate content. Food flavoring remains the primary commercial demand driver.

Commercial specifications

• Food-grade quality meeting FCC purity specifications
• Standard packaging formats suited to industrial food production, including bulk bags
• Smaller quantities for R&D use and laboratory testing
• Blended nucleotide products combining GMP-Na2 with IMP are commercially available for direct use in seasoning and snack formulations