Pepsin A

Pepsin A (CAS 9001-75-6), commonly traded as Pepsin, is a proteolytic enzyme derived from the gastric mucosa of porcine or bovine origin.

Where is Pepsin A used?

• Food manufacturing: primary processing enzyme
• Cheese and dairy: coagulant alone or blended with rennet, initiating curd formation as a cost-effective alternative to pure rennet
• Pharmaceutical production: digestive enzyme preparations and reference standard for evaluating proteolytic activity in drug formulations
• Protein hydrolysate production: breaks down animal proteins, including collagen and casein, into peptide fractions for nutritional supplements and clinical nutrition products
• Biotechnology and life science laboratories: in vitro digestion assays and antibody fragmentation
• It is essential for generating Fab and F(ab')₂ fragments and conducting digestibility testing protocols.

Good to know: Pharmaceutical-grade material is subject to tighter activity and purity specifications. Porcine-derived material dominates supply, though bovine-sourced grades are available for markets with specific sourcing requirements.

Commercial specifications

• Standardized by enzymatic activity expressed in units per milligram