Pancreatin

CAS Number
8049-47-6
EC Number
232-468-9

What is Pancreatin?

Pancreatin (CAS 8049-47-6) is a multi-enzyme concentrate derived from porcine or bovine pancreatic tissue, containing a defined mixture of proteases, lipases, and amylases.

Where is Pancreatin used?

  • Pharmaceuticals: active substance in pancreatic enzyme replacement therapy products, often enteric-coated capsules or tablets for exocrine pancreatic insufficiency
  • Food and nutrition: production of protein hydrolysates and pre-digested formulas, including hypoallergenic infant feed ingredients
  • Biotechnology and research: in vitro digestion models, bioavailability testing, and preparation of peptide fractions
  • Leather and textile industries: bating and degumming processes requiring controlled proteolytic activity
  • It is essential where enzymatic digestion or hydrolysis of proteins, fats, and starches is required.

Good to know: Cold-chain handling is typically required during transport and storage to preserve enzymatic activity.

Commercial specifications

  • Standard grades include USP, BP, and Ph. Eur.
  • Potency specifications such as 4X, 8X, and 10X relative to the reference standard
  • Bulk supply in fiber drums or multi-layer bags

Other Names (Synonyms)

2-(benzylsulfonyl)-1-(morpholin-4-yl)ethanone|Pancreatin, from porcine stomach mucose|Diastase vera|Intrazyme|Pankreon|Pancrex V

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What are the physical properties of Pancreatin?

Density 1.4-1.52
Appearance Pancreatin is a yellowish to cream-colored, amorphous powder with a strong odor. Slightly soluble in water. Hazard Identification (based on NFPA-704 M Rating System): Health 1, Flammability 1, Reactivity 0. Sparingly soluble in water.
Color beige
Form powder
Water Solubility Soluble in water. Insoluble in alcohol and ether.
Vapor Pressure 0Pa at 25℃
pH 5-6 (20°C, 10g/L in H2O)
Log P -1.3 at 20℃ and pH5.7-5.8

Which trade and regulatory codes apply to Pancreatin?

HS Code 35079090
Storage Class 13 - Non Combustible Solids
WGK (Germany) 1
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