SoleChem

Retinyl acetate

CAS
127-47-9
EC
208-537-4
Mol. Weight
328.5 g/mol

Description

Retinyl acetate (CAS 127-47-9), also known as retinol acetate and vitamin A alcohol acetate, is the acetic acid ester form of vitamin A used as a nutritional supplement and active ingredient across pharmaceutical, food, and cosmetic manufacturing.

Its esterified structure offers improved stability over free retinol, making it a preferred sourcing choice for formulators requiring consistent potency through processing and shelf life. In dietary supplements and fortified foods, it delivers measurable vitamin A activity.

It is used to standardize nutrient content in capsules, tablets, and fortified staples such as flour, milk, and infant formula. Pharmaceutical manufacturers incorporate it into vitamin A deficiency treatments and multivitamin preparations where precise dosing is critical.

Regulatory compliance is ensured through adherence to USP and BP standards. In personal care, it functions as an active in anti-aging creams, serums, and moisturizers targeting skin renewal and moisture retention.

Food producers also use it to restore vitamin A levels lost during processing in margarine and cooking oils. Retinyl acetate is supplied as a crystalline powder, oily liquid, or in stabilized beadlet form for dry blending applications.

Standard grades include food-grade specifications, with potency typically expressed in International Units (IU) per gram. Beadlet formulations with varying IU concentrations are commonly available to support direct compression or powder mixing.

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Physical Properties

Melting Point 57-58 °C
Boiling Point 406.22°C (rough estimate)
Density 1.0474 (rough estimate)
Flash Point 14°C
Appearance Crystalline
Color Yellow powder
Odor Amine like
Form solid or viscous liquid
Water Solubility soluble
Refractive Index 1.547-1.555
Log P 9.4 at 25℃

Safety & Handling (Learn More)

Danger GHS07 GHS08
Hazard Statements
H315 Causes skin irritation
H360 May damage fertility or the unborn child
H361 Suspected of damaging fertility or the unborn child
H413 May cause long lasting harmful effects to aquatic life
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P264 Wash … thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P318 IF exposed or concerned, get medical advice.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P302+P352 IF ON SKIN: Wash with plenty of water.
P332+P317 Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.

Trade & Regulatory

HS Code 29362100
UN Number 1170
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 2

Documentation

Other Names

Vitamin A alcohol acetate|Retinol acetate|O(15)-acetylretinol|all-trans-Vitamin A acetate|all-trans-Retinyl acetate|all-trans-Retinol acetate|Vitamin A acetate|Vitamin A1 acetate

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