Tocopheryl Nicotinate

Tocopheryl Nicotinate (CAS 16676-75-8) is a lipophilic ester formed by the conjugation of tocopherol and nicotinic acid, combining the antioxidant character of Vitamin E with the vasodilatory properties associated with the niacin moiety. Insoluble in water and stable in fatty matrices, it is well suited to formulations requiring both oxidative protection and peripheral circulation activity in a single functional ingredient. In personal care and cosmetics, Tocopheryl Nicotinate is used primarily as a skin-conditioning antioxidant and mild warming agent. Its vasodilatory effect makes it a recognised functional actives choice in scalp treatments, warming massage products, and topical preparations where localised blood-flow stimulation is a formulation objective. It is listed under the INCI name Tocopheryl Nicotinate and is compatible with a broad range of emollient and carrier oil systems.

For pharmaceutical and nutraceutical applications, the ingredient functions as a stabilising antioxidant excipient and as an active form of Vitamin E in topical drug products and speciality supplement formats. Formulators should note that this ester form is not currently listed under Annex II of Directive 2002/46/EC for use in EU food supplements; regulatory suitability for a given market application should be confirmed prior to formulation. Where Vitamin E activity is the relevant claim basis, EU authorised health claims under Regulation (EC) No 432/2012 recognise that Vitamin E contributes to the normal protection of cells from oxidative stress. The ingredient is available in cosmetic-grade and pharmaceutical-grade designations. Appearance is typically a yellow to yellowish solid or viscous material depending on purity and processing. SoleChem can supply against customer-specified quality parameters, with full batch documentation including Certificate of Analysis (CoA), Safety Data Sheet (SDS), and Technical Data Sheet (TDS) provided as standard.

Packaging options are aligned with standard bulk procurement requirements. Material is offered in 25 kg fibre drums for volume orders, with 1–5 kg quantities available for development batches, stability trials, and qualification programmes. Cold-chain or controlled-temperature storage recommendations are followed in accordance with supplier specifications to maintain product integrity during transit. SoleChem sources Tocopheryl Nicotinate from audited manufacturing partners with established supply chain traceability. Documentation to support regulatory submissions, internal quality systems, and customer audits is available upon request. Lead times and minimum order quantities are confirmed at the enquiry stage.

For technical specifications, regulatory support documentation, or to request a sample, contact the SoleChem product team directly. We work with procurement and formulation teams across Europe to ensure consistent supply and complete technical transparency.