Organometallic Compounds
REACH
Pinacolborane
CAS Number
25015-63-8
EC Number
607-485-3
Abbreviation
HBpin
Industries: Pharma & Healthcare
What is Pinacolborane?
Pinacolborane (CAS 25015-63-8), commonly abbreviated as HBpin, is a selective hydroboration reagent used in pharmaceutical synthesis and specialty chemical manufacturing.
Where is Pinacolborane used?
- Pharmaceutical and API synthesis: catalytic hydroboration of alkenes and alkynes
- Medicinal and process chemistry: installation of boronic ester handles on complex scaffolds with high regioselectivity
- Specialty monomers: synthesis of boron-functionalized monomers for controlled polymerization
- Biotechnology: preparation of boron-tagged probes and labeled building blocks for biological screening
- It delivers boron functionality to unsaturated substrates under mild, controllable conditions.
Good to know: Moisture-sensitive; inert-atmosphere packaging formats are used. High-purity grades are available for sensitive synthetic applications.
Commercial specifications
- Purity typically 95% and above
- Research quantities through multi-kilogram industrial packaging
Other Names (Synonyms)
4,4,5,5-tetramethyl-1,3,2-dioxaborolane|1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-|RefChem:863303|2,3-Butanediol, 2,3-dimethyl-, cyclic ester with boronic acid|HBpin
What are the physical properties of Pinacolborane?
Boiling Point 42-43 °C
Density 0.882 g/mL at 25 °C(lit.)
Flash Point 41 °F
Appearance Clear colorless liquid
Color Clear colorless to light yellow
Form Liquid
Vapor Pressure 29-119.9hPa at 20-50℃
Refractive Index n 20/D 1.396(lit.)
How is Pinacolborane classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant
Hazard Statements
H220 Extremely flammable gas
H225 Highly Flammable liquid and vapor
H260 In contact with water releases flammable gases which may ignite spontaneously
H261 In contact with water releases flammable gas
H315 Causes skin irritation
H318 Causes serious eye damage
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P222 Do not allow contact with air.
P223 Do not allow contact with water.
Which trade and regulatory codes apply to Pinacolborane?
HS Code 29209090
UN Number 3398
ADR Class 4.3
Packing Group II
Storage Class 4.3 - Hazardous materials which set free flammable gases upon contact with water
WGK (Germany) 3