3-Hexyne-2,5-diol

CAS Number
3031-66-1
EC Number
221-209-5

What is 3-Hexyne-2,5-diol?

3-Hexyne-2,5-diol (CAS 3031-66-1), also marketed as Golpanol HD, is an acetylenic diol used as a reactive intermediate and functional building block in specialty chemical manufacturing.

Where is 3-Hexyne-2,5-diol used?

  • Pharmaceutical manufacturing: intermediate in the synthesis of active ingredients and chiral compounds, with the acetylenic backbone providing a defined structural scaffold
  • Polymer production: monomer or chain-transfer component in specialty polyurethanes and polyesters, where the alkyne functionality enables post-polymerization modification
  • Metalworking and lubricant formulations: corrosion inhibitor additive and surface-active component in aqueous cutting fluids for industrial machinery
  • It also acts as a polymerization initiator in controlled synthesis applications requiring hydroxyl-terminated oligomers.

Commercial specifications

  • Purity specifications commonly range from 97% to 99%+ for synthesis-grade applications.
  • Packaging options generally include drum and IBC quantities suited to industrial procurement volumes.

Other Names (Synonyms)

Hex-3-yne-2,5-diol|Golpanol hd

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What are the physical properties of 3-Hexyne-2,5-diol?

Melting Point 69-90 °C
Boiling Point 121 °C @ Press: 13 Torr
Density 1.0221 g/cm³ @ Temp: 20 °C
Flash Point >230 °F
Color Pale Yellow
Form Oil
Vapor Pressure 0.1Pa at 20℃
Refractive Index n 20/D 1.473(lit.)
Log P -0.24 at 25℃

How is 3-Hexyne-2,5-diol classified and handled safely? Learn More

Danger
GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard

Hazard Statements

H300 Fatal if swallowed
H301 Toxic if swallowed
H315 Causes skin irritation
H317 May cause an allergic skin reaction

Precautionary Statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.

Which trade and regulatory codes apply to 3-Hexyne-2,5-diol?

UN Number 2811
ADR Class 6.1
Packing Group III
WGK (Germany) 2
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