Nordihydroguaiaretic acid

CAS Number
500-38-9
EC Number
207-903-0
Abbreviation
NDGA

What is Nordihydroguaiaretic acid?

Nordihydroguaiaretic acid (CAS 500-38-9), commonly identified in procurement as NDGA, is a naturally derived phenolic antioxidant extracted from the creosote bush.

Where is Nordihydroguaiaretic acid used?

  • Food processing: lipid oxidation inhibitor and stabilizer that delays rancidity in fats, oils, and lipid-rich formulations
  • Pharmaceutical: antioxidant excipient protecting active ingredients and lipid-based drug delivery systems from oxidative degradation
  • Personal care and cosmetics: antioxidant protection and UV stabilization in creams, lotions, and suncare formulations
  • Research and specialty chemical buyers source NDGA as a reference standard or active compound in investigational formulations targeting oxidative stress pathways.

Commercial specifications

  • High-purity grades for pharmaceutical and analytical applications
  • Packaging from small laboratory quantities to bulk industrial supply

Other Names (Synonyms)

NDGA|nordihydroguaretic acid|2,3-bis(3,4-dihydroxybenzyl)butane|RefChem:854717|4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol|Norhydroguaiaretic acid|Norguaiaretic acid, dihydro-|1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-

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What are the physical properties of Nordihydroguaiaretic acid?

Melting Point 185.5 °C
Boiling Point 363.4°C (rough estimate)
Density 1.0772 (rough estimate)
Appearance light yellow crystalline solid
Color White to off-white
Form Powder
Water Solubility slightly soluble
Refractive Index 1.4230 (estimate)
Log P 4.640 (est)

How is Nordihydroguaiaretic acid classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.

Which trade and regulatory codes apply to Nordihydroguaiaretic acid?

HS Code 29072990
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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