alpha-linolenic acid

Alpha-linolenic acid (CAS 463-40-1), commercially known as ALA, is an essential omega-3 fatty acid sourced primarily from flaxseed, chia, and other plant-based oils.

Where is alpha-linolenic acid used?

• Food and dietary supplements: nutritional supplement component in fortified oils, capsules and nutritional blends
• Botanical omega-3 ingredient in infant formula.
• Personal care: skin-conditioning agent in facial oils, moisturizers and hair treatments
• Cosmetic preparations for antistatic, cleansing, emollient, skin conditioning and surfactant properties.
• Pharmaceuticals: emulsifier in softgel and lipid-based drug delivery systems
• In specialty emulsions it contributes to dispersion stability where polyunsaturated fatty acid composition is a labeled specification.
• Oils rich in omega-3 fatty acids (mainly alpha-linolenic acid) do not withstand frying or intense heating and must be used for seasoning.

Formulation notes

• High LogP and very low water solubility; formulation strategies must focus on improving bioavailability and stability.

Typical specification

• Appearance is a clear light yellow to yellow liquid.
• Soluble in ethanol at 100 mg/mL.

Regulatory status

• The French food safety agency issued an opinion on the use of linseed oil in a food supplement with a guaranteed content of alpha-linolenic acid.

Storage, packaging and handling

• Relatively sensitive to oxidation and goes rancid faster than many other oils.
• Active ingredients can be destroyed by exposure to air, heat or light.
• As a polyunsaturated fatty acid, it can undergo oxidative degradation, requiring appropriate antioxidants and controlled storage conditions.

Frequently asked questions about alpha-linolenic acid

How is alpha-linolenic acid quantified in quality control?

It is quantified by GC-FID after esterification. Standardized analytical characterization, including fatty acid profile and peroxide value, is recommended for quality assurance when sourcing alpha-linolenic acid APIs.

What oral formulation types are available for alpha-linolenic acid?

It is available in oral formulations including capsules, gelatin-coated capsules, film-coated tablets, and kits.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.