Tetrahydrocortisol

Tetrahydrocortisol (CAS 53-02-1), also known as Tetrahydro F, is a reduced metabolite of cortisol used as a reference standard and pharmaceutical intermediate in steroid research and drug development. It supports analytical workflows and synthesis programs where structurally characterized corticosteroid derivatives are required. In pharmaceutical development, it serves as a certified reference standard for quantifying cortisol metabolites.

This material is used in urine and plasma during clinical and preclinical studies. Bioanalytical laboratories use it to validate LC-MS/MS and immunoassay methods for adrenal function testing and endocrine disorder diagnostics. In steroid synthesis research, it functions as a key intermediate for producing structurally related corticosteroid compounds. Biotechnology and life sciences organizations also use it in metabolomics studies profiling HPA axis activity.

The product is essential for steroid hormone pathways and metabolic profiling. It is supplied as a white to off-white crystalline powder in small-quantity research formats, typically ranging from milligram to low-gram quantities. It is available in certified reference standard grade with documented purity, commonly ≥97% or ≥98% by HPLC. Pharmaceutical-grade material with full documentation packages is obtainable for GMP-compliant development programs.