Tetrahydrocortisol
CAS Number
53-02-1
EC Number
200-159-8
Industries: Pharma & Healthcare
What is Tetrahydrocortisol?
Tetrahydrocortisol (CAS 53-02-1), also known as Tetrahydro F, is a reduced metabolite of cortisol used as a reference standard and pharmaceutical intermediate in steroid research and drug development.
Where is Tetrahydrocortisol used?
- Pharmaceutical development: certified reference standard for quantifying cortisol metabolites
- Clinical and preclinical studies: used in urine and plasma
- Bioanalytical laboratories: validate LC-MS/MS and immunoassay methods for adrenal function testing and endocrine disorder diagnostics
- Steroid synthesis research: key intermediate for structurally related corticosteroid compounds
- Biotechnology and life sciences: metabolomics studies profiling HPA axis activity
- It supports analytical workflows and synthesis programs requiring structurally characterized corticosteroid derivatives.
Commercial specifications
- Certified reference standard grade with documented purity, commonly ≥97% or ≥98% by HPLC
- Pharmaceutical-grade material with full documentation packages for GMP-compliant development programs
Other Names (Synonyms)
Tetrahydro F|Tetrahydrocompound F|Cortisol, tetrahydro-|5beta-Tetrahydrocortisol|3alpha,5beta-Tetrahydrocortisol|3alpha,11beta,17,21-Tetrahydroxy-5beta-pregnan-20-one|Pregnan-20-one, 3,11,17,21-tetrahydroxy-, (3α,5β,11β)-|5β-Pregnan-20-one, 3α,11β,17,21-tetrahydroxy-
What are the physical properties of Tetrahydrocortisol?
Melting Point 202-204 °C
Boiling Point 65-67 °C(lit.)
Density 0.889 g/mL at 25 °C(lit.)
Flash Point 1 °F
Color <10(APHA)
Form Solid
Vapor Pressure 114 mm Hg ( 15 °C)
Refractive Index n 20/D 1.407(lit.)
Which trade and regulatory codes apply to Tetrahydrocortisol?
UN Number 2056
ADR Class 3
Packing Group II
Storage Class 11 - Combustible Solids
WGK (Germany) 1