Ethyl 2-aminothiazole-4-carboxylate

Ethyl 2-aminothiazole-4-carboxylate (CAS 5398-36-7) is a thiazole-based building block used primarily as a pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients.

The compound's aminothiazole scaffold makes it a recognized starting material or coupling partner in multi-step synthetic routes targeting antibiotics, antivirals, and other therapeutic compounds.

In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of cephalosporin antibiotics and related beta-lactam compounds, where the aminothiazole moiety is a structurally critical fragment.

Medicinal chemistry programs use it in the construction of heterocyclic libraries for drug discovery, particularly in campaigns targeting antimicrobial and antifungal candidates.

Contract manufacturers and API producers source it as a building block for regulated synthesis workflows requiring documented purity and traceability for high-quality chemical production.

Specialty chemical formulators also evaluate it within heterocyclic compound programs for fine chemical and agrochemical research applications across various industrial sectors.

Ethyl 2-aminothiazole-4-carboxylate is supplied as a solid powder, typically off-white to pale yellow in appearance. It is available in research quantities through to multi-kilogram commercial lots.

Purity specifications commonly offered include 97–99%+ grades suited to pharmaceutical intermediate and synthesis applications, ensuring reliability in complex chemical manufacturing processes.