Trehalose dihydrate

Trehalose dihydrate (CAS 6138-23-4) is a naturally occurring disaccharide sugar in its stable, crystalline hydrated form. Also marketed as D-(+)-Trehalose dihydrate.

Where is Trehalose dihydrate used?

• Food: protects flavor compounds, reduces moisture migration in baked goods, suppresses starch retrogradation to extend shelf life
• Pharmaceutical and biotech: stabilizes proteins, vaccines, and lyophilized biologics during freeze-drying
• Personal care: retains moisture in skin creams, serums, and lip products while supporting antioxidant stability in sensitive actives
• Confectionery and nutraceutical: functional sugar replacement with mild, clean sweetness
• It preserves molecular integrity during sensitive industrial procedures.
• Used in biopharmaceutical monoclonal antibody formulations.

Good to know: Pharmaceutical supply typically conforms to USP, Ph. Eur., BP, and EP standards. High-purity batches meet FCC and ACS quality standards.

Formulation notes

• Incompatible with strong oxidizing agents.

Typical specification

• High-purity excipient grade is available for injectable use.
• Water content is 8.65-10.80% by Karl Fischer titration, corresponding to 1.8-2.3 waters.
• Non-reducing, distinguishing it from other sugars, with a relatively low caloric value.

Regulatory status

• Meets NF, EP, JP, and ChP monograph specifications.

Storage, packaging and handling

• Store in a tightly closed container at ambient temperature in a dry place, protected from direct sunlight and moisture.
• Can be shipped at ambient temperature without any cooling measures, based on stability tests.

Frequently asked questions about Trehalose dihydrate

What purity and grade forms are available?

It is available with purity ≥98.0% (trehalose, dry basis) as white to almost white crystalline powder. It is supplied in pharmaceutical grade and food grade.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.