HATU

HATU (CAS 148893-10-1), also known as N-HATU, is a high-efficiency peptide coupling reagent for solid-phase and solution-phase peptide synthesis.

Where is HATU used?

• Pharmaceutical synthesis: assembly of complex peptide APIs including GLP-1 analogs and cyclic peptides
• Biotech and contract manufacturing: peptide libraries for drug discovery screening
• Convergent synthesis: protected amino acid fragments with reduced racemization
• Peptidomimetics and conjugates: difficult sequences and sterically hindered residues
• It activates carboxylic acids toward amide bond formation.

Good to know: Coupling efficiency directly impacts yield and purity at scale. Specifications vary by supplier, with GMP-grade material supported by full analytical documentation.

Commercial specifications

• Purity ≥98% by HPLC
• Research quantities through multi-kilogram lots for GMP manufacturing
• CoA, residual solvent data, batch traceability