HATU

HATU (CAS 148893-10-1), also known as N-HATU, is a high-efficiency peptide coupling reagent used extensively in solid-phase and solution-phase peptide synthesis. It activates carboxylic acids toward amide bond formation. This reagent enables rapid, high-yield couplings that are critical in API and peptide drug manufacturing. In pharmaceutical synthesis, it enables the assembly of complex peptide APIs including GLP-1 analogs and cyclic peptides.

Coupling efficiency directly impacts yield and purity at scale. Biotech and contract manufacturing organizations rely on it for synthesizing peptide libraries used in drug discovery screening campaigns for new medicines. It supports the preparation of protected amino acid fragments in convergent synthesis strategies, reducing racemization compared to older reagent classes. This makes it a preferred choice for modern laboratories.

Research institutions also use this activator in the synthesis of peptidomimetics and conjugates where difficult sequences or sterically hindered residues require a high-performance activator for successful results. The product is supplied as a crystalline powder, typically at purities of ≥98% by HPLC. It is available in research quantities through to multi-kilogram lots for GMP manufacturing environments across the globe.

Specifications vary by supplier, with GMP-grade material supported by full analytical documentation. This includes a CoA, residual solvent data, and batch traceability to ensure the highest quality standards are met.