Hydroxocobalamin Acetate

Hydroxocobalamin Acetate (CAS 22465-48-1) is a naturally occurring form of Vitamin B12, supplied as a crystalline powder with a molecular weight of approximately 1,388 g/mol. As the acetate salt of hydroxocobalamin, it offers a stable, well-characterised active ingredient suited to demanding formulation environments across pharmaceutical, nutraceutical, and personal care applications. In pharmaceutical and API manufacturing, Hydroxocobalamin Acetate is produced and tested to USP and Ph. Eur. standards, supporting injectable preparations, parenteral formulations, and prescription-grade supplements where rigorous purity documentation is required. Typical purity specifications reach 99% or above, with full batch traceability and certificate of analysis available upon request.

For nutraceutical and dietary supplement manufacturers, Vitamin B12 carries a recognised set of authorised EU health claims under Regulation (EC) No 432/2012. These include contributions to normal energy-yielding metabolism, functioning of the nervous system, red blood cell formation, homocysteine metabolism, the immune system, and cell division. Formulators should note that this specific form — Hydroxocobalamin Acetate — is not listed in Annex II of Directive 2002/46/EC; regulatory suitability for finished supplement labelling should be verified with your compliance team prior to use. In personal care and cosmetic applications, the ingredient functions as an antioxidant and stabiliser, supporting formulation integrity in serums, ampoules, and topical preparations where oxidative stability is a technical priority. Its compatibility with aqueous systems makes it a practical choice for water-based cosmetic matrices.

Hydroxocobalamin Acetate is sparingly soluble in water, alcohol, and methanol. This solubility profile is a relevant handling consideration during premix preparation and should be factored into dissolution protocols for both liquid and solid-dosage applications. Proper storage — sealed, away from moisture and light, at controlled low temperature — is essential to maintaining product integrity across the supply chain. SoleChem supplies Hydroxocobalamin Acetate in pharmaceutical-grade and cosmetic-grade specifications, in crystalline powder form, packaged to suit both small development lots and full production volumes. Standard packaging includes 1–5 kg units for laboratory and pilot-scale work, alongside 25 kg drums for bulk commercial requirements. Custom pack sizes can be arranged to meet specific procurement needs.

All material is supplied with complete technical documentation, including specification sheets, safety data sheets, and batch-level certificates of analysis. SoleChem maintains consistent availability across the European market, with lead times and stock positions confirmed at the point of enquiry. Contact our technical sales team to discuss grade requirements, regulatory support documentation, or sample requests.