Pyridoxamine Dihydrochloride

CAS Number
524-36-7
EC Number
208-357-6

What is Pyridoxamine Dihydrochloride?

Pyridoxamine Dihydrochloride (CAS 524-36-7) is a hydrochloride salt form of pyridoxamine, one of the three principal vitamers within the Vitamin B6 family.

Where is Pyridoxamine Dihydrochloride used?

  • Pharmaceutical and nutraceutical manufacturing: bioavailable source of Vitamin B6 activity
  • Personal care and cosmetics: scalp and hair care, including professional conditioning treatments, serums and leave-on products
  • Its water solubility supports straightforward incorporation into aqueous-phase formulations without solubilising agents.

Good to know: This specific salt form does not appear in Annex II of Directive 2002/46/EC governing food supplements; suitability for finished supplement or fortification applications should be confirmed against current regulatory requirements in each target market. Vitamin B6, as recognised under EU Regulation 432/2012, carries authorised EU health claims covering its contribution to normal protein and glycogen metabolism, red blood cell formation, normal immune system function, homocysteine metabolism regulation, and the regulation of hormonal activity.

Commercial specifications

  • Molecular weight approximately 255.1 g/mol
  • Purity not less than 98% on a dry basis; assay values commonly reported between 98% and 102.5%
  • Appearance, loss on drying, heavy metals, and residual solvent profiles are characterised in full specification sheets available upon request.
  • Small-lot quantities from 1 kg to 5 kg for pilot and R&D; bulk supply in 25 kg drums or cartons.

Other Names (Synonyms)

PYRIDOXAMINE|Pyridoxamine DiHCl|4-(aminomethyl)-5-(hydroxymethyl)-2-|4-AMINOMETHYL-5-HYDROXY-6-METHYL-3-PYRIDINEMETHANOL DIHYDROCHLORIDE|4-(AMINOMETHYL)-5-HYDROXY-6-METHYL-3-PYRIDENEMETHANOL DIHYDROCHLORIDE|4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride|Pyridorin

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What are the physical properties of Pyridoxamine Dihydrochloride?

Melting Point 226.5 °C (decomp)
Density 1.4025 (rough estimate)
Refractive Index 1.6100 (estimate)
pka pKa 3.31(H2O t = 25 I = 0.1)(Approximate)
Water Solubility Soluble in DMSO, water, or methanol /n
Appearance White crystalline powder
Color White to off-white to pale brown
Form Powder or Solid

How is Pyridoxamine Dihydrochloride classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
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