Calcium gluconate

CAS Number
299-28-5
EC Number
206-075-8

What is Calcium gluconate?

Calcium gluconate (CAS 299-28-5), also known by its food additive designation E578, is a calcium salt of gluconic acid used across food, pharmaceutical, and personal care manufacturing.

Where is Calcium gluconate used?

  • Food and beverage: firming agent and acidity regulator
  • Canned vegetables and processed dairy: maintains texture
  • Baking and dairy processing: sequestrant
  • Pharmaceuticals: direct calcium source in oral and injectable mineral supplement formulations
  • Personal care: buffers pH and chelates metal ions in skincare and haircare products
  • It functions as a mineral supplement, pH buffer, and chelating agent depending on the application context.

Commercial specifications

  • Pharmaceutical grades meet strict purity thresholds for injectable and oral dosage applications
  • Packaging typically ranges from 25 kg bags to bulk quantities depending on the intended grade

Other Names (Synonyms)

E578|D-gluconic acid, calcium salt (2:1)|D-Gluconic acid calcium salt|Calcium gluconate, anhydrous|Calcium di-gluconate|Calciofon|Calcii gluconas|Calcarea gluconica

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What are the physical properties of Calcium gluconate?

Melting Point 120 °C
Boiling Point 400°C[at 101 325 Pa]
Density 1.677[at 20℃]
Appearance white crystalline powder or granules
Color White
Odor Odorless
Form Crystals or Crystalline Powder
Water Solubility 3.3 g/100mL
Vapor Pressure 0.004Pa at 20℃
pH pH;6.0~8.0
Log P -5.31 at 20℃

Which trade and regulatory codes apply to Calcium gluconate?

HS Code 38220090
WGK (Germany) 1
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