4-hydroxy acetophenone
CAS Number
99-93-4
EC Number
202-802-8
FEMA Number
FEMA 4330
What is 4-hydroxy acetophenone?
4-Hydroxyacetophenone (CAS 99-93-4), also known commercially as piceol, is a phenolic ketone used across food, cosmetic, and industrial manufacturing.
Where is 4-hydroxy acetophenone used?
- UV-curable printing inks and packaging coatings: photoinitiator that triggers polymerization under UV exposure
- Cosmetics: antioxidant and skin-brightening active in serums and creams
- Food and beverage: flavoring ingredient under FEMA 4330, contributing phenolic and sweet notes
- Pharmaceuticals: intermediate in API synthesis where a para-substituted acetophenone scaffold is required
- It also functions as an antioxidant and flavoring agent depending on the sector.
Good to know: Approved under FEMA 4330 as a flavoring ingredient. Meets FCC, USP, Ph. Eur., BP, EP, and ACS specifications.
Commercial specifications
- Technical and high-purity grades
- Fiber drums and multi-layer bags; bulk quantities available
Other Names (Synonyms)
piceol|para-Hydroxyacetophenone|p-Hydroxyphenyl methyl ketone|p-Hydroxyacetophenone|Methyl p-hydroxyphenyl ketone|4-Acetylphenol|1-(4-hydroxyphenyl)ethanone|(4-hydroxyphenyl)ethan-1-one
What are the physical properties of 4-hydroxy acetophenone?
Melting Point 109.5 °C
Boiling Point 146-149 °C
Density 1.278 g/cm³ @ Temp: 25 °C
Flash Point 166 °C
Appearance almost white to beige crystalline powder
Color Almost white to beige
Odor at 10.00 % in dipropylene glycol. mild sweet hawthorn balsam mimosa
Form Crystalline Powder
Water Solubility 10 g/L (22 ºC)
Vapor Pressure 0.002Pa at 20℃
Refractive Index 1.5577 (estimate)
Log P 1.35 at 25℃
How is 4-hydroxy acetophenone classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
Which trade and regulatory codes apply to 4-hydroxy acetophenone?
HS Code 29145000
Storage Class 13 - Non Combustible Solids
WGK (Germany) 3