SoleChem

Rabeprazole sodium

CAS
117976-90-6
EC
629-730-3
Mol. Weight
381.4 g/mol

Description

Rabeprazole sodium (CAS 117976-90-6), also marketed under the brand name Aciphex, is a proton pump inhibitor used as an active pharmaceutical ingredient in the treatment of acid-related gastrointestinal disorders.

It functions by suppressing gastric acid secretion, making it a key API in finished dosage form manufacturing. Rabeprazole sodium is formulated into enteric-coated tablets and delayed-release capsules.

It is used for the management of conditions such as GERD, peptic ulcers, and Zollinger-Ellison syndrome. Contract manufacturers and generic drug producers source it as a primary API for solid oral dosage forms.

The material targets the gastrointestinal therapeutic segment and is also used in combination therapy formulations. It is particularly effective alongside antibiotics for H. pylori eradication regimens.

Pharmaceutical formulators evaluating bioequivalence studies or generic product development will source this material to established reference standards. It is supplied as a white to off-white crystalline powder.

It is available in pharmaceutical-grade specifications, with material typically conforming to USP, BP, or in-house pharmacopoeial standards depending on the supplier requirements.

Packaging is offered in controlled quantities suitable for R&D through to commercial-scale API manufacturing. This ensures stability and compliance for global pharmaceutical supply chains and production.

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Physical Properties

Melting Point 140-141 °C (decomp)
Appearance White Crystalline Solid
Color white to beige
Form powder
Water Solubility H2O: 10mg/mL (clear solution)

Safety & Handling (Learn More)

Warning GHS07 GHS08
Hazard Statements
H302 Harmful if swallowed
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H371 May cause damage to organs
H413 May cause long lasting harmful effects to aquatic life
Precautionary Statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P319 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P301+P317 Get emergency medical help.
P302+P352 IF ON SKIN: Wash with plenty of water.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P308+P316 Get emergency medical help immediately.
P332+P317 Get emergency medical help.
P333+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 2933399090
WGK (Germany) 3

Documentation

Other Names

Sodium rabeprazole|Aciphex|Rabeprazole sodium salt|Rabeprazole na|LY307640 sodium|Idiazole|Aciphex Sprinkle|E-3810 SODIUM

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