Pantoprazole sodium sesquihydrate

Pantoprazole sodium sesquihydrate (CAS 164579-32-2) is the stable hydrated sodium salt form of pantoprazole, used as the active pharmaceutical ingredient in proton pump inhibitor drug products. Also marketed under the brand name Pantosec.

Where is Pantoprazole sodium sesquihydrate used?

• Enteric-coated tablets
• Delayed-release capsules for acid-related gastrointestinal conditions
• Lyophilized powders for intravenous injection, where the sodium salt form supports aqueous solubility requirements
• Generic drug manufacturers produce finished dose forms targeting hospital and retail pharmacy supply chains.

Good to know: The commercially preferred form for solid and injectable dosage manufacturing due to its defined hydration state and improved handling characteristics. Formulators working on bioequivalence studies or line extensions also procure it as a reference-grade material.

Commercial specifications

• Pharmaceutical-grade specifications conforming to USP, BP, and Ph. Eur. monographs
• Documentation packages including CoA, DMF references, and ICH-compliant impurity profiles
• Packaging from small quantities for R&D use to bulk quantities for commercial manufacturing