Abacavir sulfate

Abacavir sulfate (CAS 188062-50-2), also referenced in procurement as abacavir hemisulfate or 1592U89 sulfate, is the salt form of abacavir used as the active pharmaceutical ingredient in antiretroviral drug manufacturing. It functions as a nucleoside reverse transcriptase inhibitor (NRTI) incorporated into finished dosage forms targeting HIV treatment. The primary commercial application is in the manufacture of oral solid and liquid antiretroviral formulations.

These formulations include tablets, film-coated tablets, and oral solutions for HIV-1 treatment. It is used as a key API in fixed-dose combination products, where it is co-formulated alongside other antiretroviral agents. Common co-formulations include agents such as lamivudine and dolutegravir. Generic pharmaceutical manufacturers source this material for finished dosage form production under regulatory filings including ANDAs and MAAs.

Specialty API distributors also supply it to formulators developing pediatric antiretroviral preparations. These oral liquid formats require high-purity, well-characterized material to ensure safety and efficacy. The product is supplied as a white to off-white crystalline powder. It is available in pharmaceutical-grade specifications conforming to USP and BP monographs for global compliance.

GMP-certified material is required for regulated drug product manufacturing to meet international standards. Packaging is typically offered in controlled quantities suited to standard API handling protocols.