Lamivudine
CAS Number
134678-17-4
EC Number
603-844-3
Abbreviation
3TC
Industries: Pharma & Healthcare
What is Lamivudine?
Lamivudine (CAS 134678-17-4), also known as 3TC and marketed as Heptovir, is a nucleoside reverse transcriptase inhibitor used as an active pharmaceutical ingredient.
Where is Lamivudine used?
- HIV and chronic hepatitis B: core component in branded and generic pipelines
- Oral solid dosage forms: tablets and film-coated tablets for HIV regimens, often combined with other antiretroviral APIs
- Hepatitis B antiviral therapies: key API for generic manufacturers
- Pediatric oral solutions: solubility-compatible grades
- Contract development and manufacturing organizations use it as a synthesis intermediate.
Good to know: Regulatory-grade purity is a critical procurement requirement for international safety standards. Recognized grades include USP, BP, and Ph. Eur., aligning with regulated markets in North America and Europe.
Commercial specifications
- Kilogram to metric-ton quantities
- Documentation packages supporting GMP-compliant procurement
Other Names (Synonyms)
Lamivudin|Heptovir|GR-109714X|Epivir-Hbv|beta-L-3'-Thia-2',3'-dideoxycytidine|beta-L-2',3'-Dideoxy-3'-thiacytidine|3TC|3'-Thia-2',3'-dideoxycytidine
What are the physical properties of Lamivudine?
Melting Point 160-162 °C
Boiling Point 475.4±55.0 °C(Predicted)
Density 1.73±0.1 g/cm3(Predicted)
Flash Point 9°C
Appearance White Crystalline Powder
Color white to beige
Form powder
Water Solubility 70g/L(temperature not stated)
Refractive Index -142 ° (C=1, MeOH)
How is Lamivudine classified and handled safely? Learn More
Warning
GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H361 Suspected of damaging fertility or the unborn child
H373 May causes damage to organs through prolonged or repeated exposure
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Lamivudine?
HS Code 29349900
UN Number 1230
Packing Group II
Storage Class 11 - Combustible Solids
WGK (Germany) 3