Croscarmellose sodium

Croscarmellose sodium (CAS 74811-65-7), also known as E468, is a cross-linked polymer of sodium carboxymethyl cellulose used as a superdisintegrant in solid dosage form manufacturing.

Where is Croscarmellose sodium used?

• Oral solid dosage manufacturing: incorporated into tablet formulations
• Direct compression and wet granulation to meet dissolution specifications for immediate-release products
• Standard tablets, orally disintegrating tablets and chewable formats
• Nutraceutical and dietary supplement compressed tablets requiring fast breakdown
• Veterinary tablet formulations where consistent disintegration across varying moisture conditions is a procurement requirement
• It rapidly absorbs water and swells, breaking apart compressed tablets and capsule fills to release the active ingredient.

Commercial specifications

• Pharmaceutical-grade specifications include USP/NF, Ph. Eur. and BP
• Particle size variants to suit different granulation processes