Itraconazole

Itraconazole (CAS 84625-61-6), also referenced under the development code R-51211 and the brand name Sporanox, is a broad-spectrum triazole antifungal active pharmaceutical ingredient.

Where is Itraconazole used?

• Human medicine: basis for systemic and topical antifungal drug products
• Oral capsule and oral solution formulations for systemic fungal infections, including aspergillosis, candidiasis, and onychomycosis
• Bioavailability enhancement: amorphous solid dispersions, cyclodextrin complexes, and nanoparticle systems addressing low aqueous solubility
• Veterinary medicine: antifungal preparations targeting dermatophyte and systemic infections in companion animals
• Generic drug manufacturers source it as a bulk API for capsule and liquid dosage form development.

Good to know: Particle size and polymorphic form are critical specification parameters for regulatory compliance.

Commercial specifications

• Defined polymorphic form and particle size distribution
• Micronized grades for enhanced dissolution strategies