Human albumin

Human albumin (CAS 70024-90-7), also referred to as HSA, is a plasma-derived protein sourced from human blood and processed under stringent fractionation conditions. It functions as a stabilizer, carrier, and buffering agent in pharmaceutical and biotechnology manufacturing.

In these environments, maintaining protein integrity and formulation consistency is critical. In injectable drug formulations, HSA stabilizes active proteins and peptides against aggregation and degradation during processing, freeze-drying, and storage.

Cell culture media for biopharmaceutical production rely on human albumin to support cell viability and regulate osmotic balance in serum-free and low-serum systems. This ensures optimal growth conditions for sensitive cell lines.

Vaccine and biologic manufacturing processes use it as an excipient to protect sensitive antigens and recombinant proteins from surface adsorption and thermal stress. This protection is vital for maintaining the efficacy of the final product.

Diagnostic reagent kits and in vitro assay systems incorporate HSA as a blocking agent and reference standard for calibration purposes. It provides a reliable baseline for complex laboratory testing and medical diagnostics.

Human albumin is supplied as a sterile aqueous solution, typically at 4%, 5%, 20%, or 25% concentrations, and as lyophilized powder for research and formulation use. These formats allow for flexible integration into various workflows.

Pharmaceutical-grade material is manufactured to Ph. Eur., USP, and BP monograph standards, with recombinant HSA grades available for applications requiring pathogen-free sourcing.

Bulk supply is available for industrial bioprocessing, with lot-specific documentation including viral safety testing and protein purity data. This ensures full compliance with international regulatory requirements for safety.