L-valine

CAS Number
72-18-4
EC Number
200-773-6
FEMA Number
FEMA 3444

What is L-valine?

L-Valine (CAS 72-18-4), also known by its FEMA 3444 designation, is an essential branched-chain amino acid used in pharmaceutical, nutritional, and cosmetic manufacturing.

Where is L-valine used?

  • Pharmaceuticals: active ingredient in amino acid infusion solutions and stabilizer in peptide drug formulations
  • Sports nutrition: combined with leucine and isoleucine in BCAA blends targeting muscle recovery and endurance
  • Food: flavor precursor and nutritional fortifier in functional foods, protein bars, and medical nutrition products
  • Personal care: humectant and film-forming agent in skin conditioning formulations where moisture retention is a performance requirement
  • It functions as a building block for protein synthesis, a buffering agent, and a stabilizing component in complex formulations.

Good to know: Pharmaceutical-grade material is subject to stricter purity specifications. Buyers should confirm production method and country of origin when sourcing for regulated applications.

Commercial specifications

  • Fermentation-derived material dominates the market

Other Names (Synonyms)

(2S)-2-azaniumyl-3-methylbutanoate|L-Val|L-alpha-Amino-beta-methylbutyric acid|L-(+)-alpha-Aminoisovaleric acid|2-Amino-3-methylbutyric acid|(S)-Valine|(2S)-2-Amino-3-methylbutanoic acid|Valine

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What are the physical properties of L-valine?

Melting Point 315 °C
Boiling Point 213.6±23.0 °C(Predicted)
Density 0.99962 g/cm³ (Solid) @ Temp: 25 °C
Appearance White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.
Color White
Odor odorless
Form powder
Water Solubility 85 g/L (20 ºC)
Refractive Index 28 ° (C=8, HCl)
pH 5.5-6.5 (100g/l, H2O, 20℃)
Log P 0.29

Which trade and regulatory codes apply to L-valine?

HS Code 29224995
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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